Aptamer-Modified Nanopipettes

Aptamer-modified nanopipettes – towards nanoscale chemical mapping

Author(s): Sandra Hernández Escobar, Nako Nakatsuka

Publication: Bunsen-Magazin 2025, 3, 129-132

Publisher: Deutsche Bunsen-Gesellschaft für physikalische Chemie e.V., Frankfurt

Language: English

DOI: 10.26125/j2e1-rk52

Abstract: Aptamer-modified nanopipettes have the potential for nanoscale chemical mapping when integrated with scanning ion conductance microscopy. These biosensors selectively detect neurotransmitters via target-induced aptamer folding, which alters ionic flux through the nanopore. Nanoscale tips minimize biofouling, allowing real-time monitoring of serotonin and dopamine in vitro and ex vivo. These sensors serve as nanotools for probing neuronal communication at the interface of biosystems.

Cite this:  S. Hernández Escobar, N. Nakatsuka, Bunsen-Magazin 2025, 3, 129-132, DOI: 10.26125/j2e1-rk52

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